Lin Feng-Ying C, Weisman Leonard E, Azimi Parvin H, Philips Joseph B, Clark Penny, Regan Joan, Rhoads George G, Frasch Carl E, Gray Barry M, Troendle James, Brenner Ruth A, Moyer Patricia, Clemens John D
National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-7510, USA.
J Infect Dis. 2004 Sep 1;190(5):928-34. doi: 10.1086/422756. Epub 2004 Jul 28.
The present study estimates the level of maternal immunoglobulin (Ig) G anti-group B streptococcus (GBS) type III required to protect neonates against early-onset disease (EOD) caused by this pathogen. Levels of maternal serum IgG anti-GBS type III, measured by enzyme-linked immunosorbent assay, in 26 case patients (neonates with EOD caused by GBS type III) and 143 matched control subjects (neonates colonized by GBS type III who did not develop EOD) of > or = 34 weeks gestation were compared. The probability of EOD decreased with increasing levels of maternal IgG anti-GBS type III (P = .01). Neonates whose mothers had > or = 10 microg/mL IgG anti-GBS type III had a 91% lower risk for EOD, compared with those whose mothers had levels of < 2 microg/mL. A vaccine that induces IgG anti-GBS type III levels of > or = 10 microg/mL in mothers can be predicted to offer a significant degree of protection against EOD caused by this pathogen.
本研究评估了母亲血清免疫球蛋白（Ig）G抗B族链球菌（GBS）Ⅲ型的水平，该水平对于保护新生儿免受此病原体引起的早发型疾病（EOD）至关重要。通过酶联免疫吸附测定法检测26例病例患者（由GBSⅢ型引起EOD的新生儿）和143例匹配的对照受试者（GBSⅢ型定植但未发生EOD的≥34周妊娠新生儿）的母亲血清IgG抗GBSⅢ型水平，并进行比较。EOD的发生概率随着母亲IgG抗GBSⅢ型水平的升高而降低（P = 0.01）。与母亲IgG抗GBSⅢ型水平<2μg/mL的新生儿相比，母亲IgG抗GBSⅢ型水平≥10μg/mL的新生儿发生EOD的风险降低了91%。可以预测，一种能使母亲体内IgG抗GBSⅢ型水平≥10μg/mL的疫苗将为预防该病原体引起的EOD提供显著程度的保护。
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