Baker C J, Edwards M S, Kasper D L
Pediatrics. 1981 Oct;68(4):544-9.
The role of maternally acquired antibody to native type III polysaccharide of group B Streptococcus as a determinant of susceptibility for infant systemic infection was investigated. Sera from 111 acutely ill infants with type III group B streptococcal bacteremia and/or meningitis and their mothers, and cord sera from 45 healthy neonates and their mothers who had type III group B streptococcal vaginal colonization at delivery were studied. Sera from each of 111 acutely ill infants contained very low levels of antibody (less than 1.7 microgram/ml, median 0.4 microgram/ml), and a significant correlation with maternal levels was tested for early onset infection (median 0.6 microgram/ml; 4 = .76; P less than .01). Women whose infants remained well had antibody levels greater than 2 microgram/ml in their sera (73%) more often than those whose infants developed symptomatic infection (17%) (P less than .001), and the median level in their sera (12.6 microgram/ml) was considerably higher. Study of sera obtained during convalescence from 86 surviving infants indicated a poor antibody response to infection. In contrast, high levels of antibody were detected in sera from each of five convalescent women with postpartum bacteremia. These data extend earlier observations suggesting the correlation between low levels of type-specific antibody in serum and risk for systemic infection with type III strains of group B streptococci.
研究了母体获得的抗B族链球菌天然III型多糖抗体作为婴儿全身感染易感性决定因素的作用。对111名患有III型B族链球菌菌血症和/或脑膜炎的急性病婴儿及其母亲的血清，以及45名健康新生儿及其在分娩时阴道有III型B族链球菌定植的母亲的脐带血清进行了研究。111名急性病婴儿的血清中抗体水平都非常低（低于1.7微克/毫升，中位数为0.4微克/毫升），对早发型感染检测到其与母体抗体水平有显著相关性（中位数为0.6微克/毫升；r = 0.76；P < 0.01）。婴儿保持健康的女性血清中抗体水平高于2微克/毫升的比例（73%）高于其婴儿出现症状性感染的女性（17%）（P < 0.001），且她们血清中的中位数水平（12.6微克/毫升）要高得多。对86名存活婴儿恢复期获得的血清研究表明，感染后的抗体反应较差。相比之下，在五名产后菌血症恢复期女性的血清中均检测到高水平抗体。这些数据扩展了早期观察结果，提示血清中低水平的型特异性抗体与III型B族链球菌全身感染风险之间存在相关性。
