备受瞩目的信号黏蛋白。

Signaling mucins in the (S)limelight.

作者信息

Clevers Hans

机构信息

Hubrecht Laboratory, Center for Biomedical Genetics, Uppsalalaan 8, Utrecht 3584 CT, The Netherlands.

出版信息

Dev Cell. 2004 Aug;7(2):150-1. doi: 10.1016/j.devcel.2004.07.013.

DOI:10.1016/j.devcel.2004.07.013

PMID:15296711

Abstract

Mucins may be the ugly ducklings of molecular biology. Their large size, repetitive nature, and unglamorous biological activities have not favored their study. However, integral membrane mucins have conserved intracellular C termini that may influence intracellular signaling. In a recent issue of Genes & Development, Cullen et al. show that the C terminus of membrane mucin-like Msb2 activates a CDC42/MAPK cascade to control filamentous growth of baker's yeast.

摘要

黏蛋白可能是分子生物学中的丑小鸭。它们体积庞大、具有重复性且生物学活性平淡无奇，这些因素都不利于对它们的研究。然而，整合膜黏蛋白具有保守的细胞内C末端，这可能会影响细胞内信号传导。在最近一期的《基因与发育》杂志上，卡伦等人表明，膜黏蛋白样Msb2的C末端激活了CDC42/丝裂原活化蛋白激酶级联反应，以控制面包酵母的丝状生长。