Larsen A, Sivertsen E, Semb G
Scand J Thorac Cardiovasc Surg. 1978;12(3):189-96.
Single aortic valve replacement was performed in 110 patients at Ullevål Hospital, Oslo, between 1971 and 1976. The follow-up period was 1 to 6 years (mean 31 months). The early postoperative mortality was 6.3% and the late mortality 8.2%. Postoperatively 44% of the surviving patients were in the N.Y.H.A. functional class I and 55% in class II, while 71% of the patients were in class III or IV pre-operatively. Objective evidence of improvement was shown by reduction in mean heart volume from 610 ml/m2 pre-operatively to 512 ml/m2 postoperatively (p less than 0.001). Electrocardiographic signs of left ventricular hypertrophy, measured as the combined voltage of Smax and Rmax in V1 to V6, were 56mV pre-operatively and 42 mV postoperatively (p less than 0.001). Myocardial failure was the main cause of death postoperatively. Sudden death occurred in 5 of the 9 patients in the late mortality group. Old age at the time of operation (65 to 71 years) was not associated with increased risk of death and complications, while alcoholism did increase the mortality rate.
1971年至1976年间，奥斯陆于勒瓦尔医院对110例患者实施了单纯主动脉瓣置换术。随访期为1至6年（平均31个月）。术后早期死亡率为6.3%，晚期死亡率为8.2%。术后存活患者中，44%处于纽约心脏协会（NYHA）心功能I级，55%处于II级，而术前71%的患者处于III级或IV级。平均心脏容积从术前的610 ml/m²降至术后的512 ml/m²（p<0.001），显示出客观的改善证据。以V1至V6导联中Smax与Rmax的电压总和衡量的左心室肥厚心电图征象，术前为56mV，术后为42mV（p<0.001）。心肌衰竭是术后主要死亡原因。晚期死亡组的9例患者中有5例猝死。手术时年龄较大（65至71岁）与死亡和并发症风险增加无关，而酗酒确实会增加死亡率。
