Rowley Matthew, Grothey Erin, Couch Fergus J
Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
J Mammary Gland Biol Neoplasia. 2004 Apr;9(2):109-18. doi: 10.1023/B:JOMG.0000037156.64331.3f.
TBX2 and TBX3 are members of a family of genes encoding developmental transcription factors, characterized by a 200 amino acid DNA binding domain (T-box). Tbx2 and Tbx3 are closely related T-box proteins that have been implicated in development of a number of different tissues including the mammary gland. TBX3 is required for normal mammary development in mouse models and in patients with ulnar-mammary syndrome (UMS). In addition to a role in development, TBX2 and TBX3 have been implicated in tumor development through downregulation of the alternative reading frame (ARF) tumor suppressor and an associated bypass of senescence. Here we review the current information on the roles of Tbx2 and Tbx3 in mammary gland development and tumorigenesis.
TBX2和TBX3是编码发育转录因子的基因家族成员，其特征在于具有200个氨基酸的DNA结合结构域（T盒）。Tbx2和Tbx3是密切相关的T盒蛋白，与包括乳腺在内的许多不同组织的发育有关。在小鼠模型和尺骨-乳腺综合征（UMS）患者中，正常乳腺发育需要TBX3。除了在发育中的作用外，TBX2和TBX3还通过下调可变阅读框（ARF）肿瘤抑制因子和相关的衰老旁路参与肿瘤发生。在这里，我们综述了关于Tbx2和Tbx3在乳腺发育和肿瘤发生中作用的当前信息。
