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A 'Goldmine' for digging cancer-specific targets: the genes essential for embryo development but non-essential for adult life.

作者信息

Yu Xiaobin, Xu Jianming

机构信息

Department of Molecular and Cellular Biology, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

出版信息

J Mol Cell Biol. 2020 Sep 1;12(9):669-673. doi: 10.1093/jmcb/mjaa024.

DOI:10.1093/jmcb/mjaa024
PMID:32470104
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7749735/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e388/7749735/144b29bcb2bc/mjaa024f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e388/7749735/61a9a68d96f7/mjaa024f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e388/7749735/144b29bcb2bc/mjaa024f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e388/7749735/61a9a68d96f7/mjaa024f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e388/7749735/144b29bcb2bc/mjaa024f2.jpg

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Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau.在成年小鼠中耗尽 Trim28 耐受性良好，并降低α-突触核蛋白和 tau 的水平。
Front Oncol. 2022 Nov 15;12:1023072. doi: 10.3389/fonc.2022.1023072. eCollection 2022.
4
Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes.整合多组学数据揭示去泛素化酶的功能和治疗潜力。
Elife. 2022 Jun 23;11:e72879. doi: 10.7554/eLife.72879.
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J Pers Med. 2022 Mar 18;12(3):494. doi: 10.3390/jpm12030494.
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