Lo Hui-Chen, Lin Su-Chen, Wang Yu-Mei
Department of Bioscience Technology, Chang-Jung Christian University, Tainan 711, Taiwan.
Clin Biochem. 2004 Aug;37(8):666-72. doi: 10.1016/j.clinbiochem.2004.02.002.
The aim of this study was to investigate the relationship between cytokines, leptin and vascular tone-related chemokine and nitric oxide (NO) in type 1 diabetic children.
Serum samples were collected from 58 children with type 1 diabetes and 33 of their healthy siblings.
Serum interleukin (IL)-8 was significantly higher and serum nitric oxide was significantly lower in the children with diabetes than in their healthy siblings. Stepwise regression analysis showed that there were significantly positive correlations between IL-1beta and IL-6, IL-1beta and nitric oxide, IL-4 and tumor-necrosis factor (TNF)-alpha, IL-4 and leptin, IL-8 and IL-2, and interferon (IFN)-gamma and IL-6, as well as significantly inversed correlations between IL-6 and IL-2, IL-8 and interferon-gamma, and leptin and TNF-alpha in siblings, not in the children with diabetes. However, there were significantly positive correlations between IL-2 and IL-4, IL-2 and leptin, IL-4 and IL-6, and TNF-alpha and IL-6 in children with diabetes.
Our results suggest that the alterations of circulating IL-8 and nitric oxide levels and cytokine network in children with diabetes may be associated with the cardiovascular disease in their adulthood.
本研究旨在探讨1型糖尿病儿童细胞因子、瘦素与血管张力相关趋化因子及一氧化氮（NO）之间的关系。
收集了58例1型糖尿病儿童及其33名健康同胞的血清样本。
糖尿病儿童血清白细胞介素（IL）-8显著升高，血清一氧化氮显著降低。逐步回归分析显示，在同胞中，IL-1β与IL-6、IL-1β与一氧化氮、IL-4与肿瘤坏死因子（TNF）-α、IL-4与瘦素、IL-8与IL-2以及干扰素（IFN）-γ与IL-6之间存在显著正相关，而IL-6与IL-2、IL-8与干扰素-γ以及瘦素与TNF-α之间存在显著负相关，但在糖尿病儿童中不存在。然而，糖尿病儿童中IL-2与IL-4、IL-2与瘦素、IL-4与IL-6以及TNF-α与IL-6之间存在显著正相关。
我们的结果表明，糖尿病儿童循环IL-8和一氧化氮水平及细胞因子网络的改变可能与他们成年后的心血管疾病有关。
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