血清白细胞介素（IL）-6、IL-1β、肿瘤坏死因子-α和瘦素水平及其在抑郁症中的相关性。
Levels of serum interleukin (IL)-6, IL-1beta, tumour necrosis factor-alpha and leptin and their correlation in depression.
作者信息
Yang Kun, Xie Guangrong, Zhang Zhongxing, Wang Changhong, Li Wenbo, Zhou Weiqiang, Tang Yanqing
机构信息
Mental Health Institute of the 2nd Xiangya Hospital, Central Southern University, Changsha, China.
出版信息
Aust N Z J Psychiatry. 2007 Mar;41(3):266-73. doi: 10.1080/00048670601057759.
OBJECTIVE
To investigate the relationship between leptin and cytokines in depressed patients.
METHODS
Thirty-three unmedicated patients (24 female, nine male) with depressive disorder and 23 healthy controls (16 female, seven male) were assessed for serum levels of interleukin (IL)-6, IL-1beta, tumour necrosis factor-alpha (TNF-alpha) and leptin.
RESULTS
Levels of IL-6 and TNF-alpha in depressed patients were higher than in normal controls. There were significantly lower leptin levels in depressed patients than in normal controls. There were also significant differences in the leptin levels, being higher in female than in male patients, and in female than in male controls.
CONCLUSIONS
IL-6 and TNF-alpha cytokines and leptin are important in the psychoimmunology of depressed patients. There were gender differences in leptin levels in depression.
目的
探讨抑郁症患者瘦素与细胞因子之间的关系。
方法
对33例未接受药物治疗的抑郁症患者（24例女性，9例男性）和23例健康对照者（16例女性，7例男性）的血清白细胞介素（IL）-6、IL-1β、肿瘤坏死因子-α（TNF-α）和瘦素水平进行评估。
结果
抑郁症患者的IL-6和TNF-α水平高于正常对照组。抑郁症患者的瘦素水平显著低于正常对照组。瘦素水平也存在显著差异，女性患者高于男性患者，女性对照者高于男性对照者。
结论
IL-6和TNF-α细胞因子以及瘦素在抑郁症患者的心理免疫学中具有重要作用。抑郁症患者的瘦素水平存在性别差异。
Zotero 插件