Takeda T, Wakasugi T, Katsumoto Y, Sakita I, Nagaoka H, Morimoto H, Tsujinaka T, Monden T, Shiozaki H, Shimano T
Dept. of Surgery 2, Osaka University Medical School.
Gan To Kagaku Ryoho. 1992 Aug;19(10 Suppl):1458-60.
We have reported the intratumoral injection of OK/fbg is a very effective immunotherapy for colorectal cancer. In this study, we injected OK/fbg into gastric cancer. Histopathological examinations revealed the formation of fibrin fibers, marked infiltration of inflammatory cells and regression of tumor tissue. Seven days after injection, cytotoxicity of splenic lymphocytes was significantly high and HLA-DR, CD25+ splenic lymphocytes were increased. But there was no significant change in peripheral blood and lymph node lymphocytes. On the contrary, several hours after injection, cytotoxicity and surface markers were changed in peripheral blood and lymph node lymphocytes. However, there was no change in splenic lymphocytes. We suppose that activation of splenic lymphocytes was caused by activation of peripheral blood and regional lymph nodes.
我们曾报道瘤内注射OK/fbg对结直肠癌是一种非常有效的免疫疗法。在本研究中，我们将OK/fbg注射到胃癌中。组织病理学检查显示有纤维蛋白纤维形成、炎性细胞显著浸润以及肿瘤组织消退。注射后7天，脾淋巴细胞的细胞毒性显著升高，且HLA - DR、CD25 +脾淋巴细胞增加。但外周血和淋巴结淋巴细胞无显著变化。相反，注射后数小时，外周血和淋巴结淋巴细胞的细胞毒性及表面标志物发生了变化。然而，脾淋巴细胞没有变化。我们推测脾淋巴细胞的激活是由外周血和区域淋巴结的激活引起的。
