基于微型正电子发射断层扫描的放射性标记硼化合物[18F]FBPA-F在F98胶质瘤大鼠中的药代动力学分析。

MicroPET-based pharmacokinetic analysis of the radiolabeled boron compound [18F]FBPA-F in rats with F98 glioma.

作者信息

Chen J C, Chang S M, Hsu F Y, Wang H E, Liu R S

机构信息

Department of Medical Radiation Technology, Institute of Radiological Sciences, National Yang-Ming University, 155 Li-Nong Street, Sec 2, Taipei, 112, Taiwan.

出版信息

Appl Radiat Isot. 2004 Nov;61(5):887-91. doi: 10.1016/j.apradiso.2004.05.056.

DOI:10.1016/j.apradiso.2004.05.056

PMID:15308163

Abstract

Boron neutron capture therapy (BNCT) is one of the effective methods of radiation therapy for the treatment of tumors such as malignant glioma. Boronophenylalanine ((10)B-BPA) solution has been used as a potential boron carrier for such a treatment. The aim of this study is to investigate 4-borono-2-[(18)F]-fluoro-l-phenylalanine-fructose ([(18)F]FBPA-F) in rats injected in the brain with glioma using in vivo small animal positron emission tomography (PET) imaging (microPET). Male Fischer 344 rats with F98 glioma in the left brain were used for these studies. Dynamic PET imaging of [(18)F]FBPA-F was performed on the 13th day after tumor inoculation. Arterial blood sampling was performed to obtain an input function for tracer kinetic modeling. The accumulation ratios of [(18)F]FBPA-F for the glioma-to-normal brain approached 3. The uptake characteristics of BPA-F and [(18)F]FBPA-F were similar. The results indicate that 4h after BPA-F injection would be the optimal irradiation time for BNCT. Rate constants were estimated using a three-compartment model. This study provides useful information for the clinical application of BNCT in patients with brain tumors.

摘要

硼中子俘获疗法（BNCT）是治疗恶性胶质瘤等肿瘤的有效放射治疗方法之一。硼代苯丙氨酸（（10）B - BPA）溶液已被用作这种治疗的潜在硼载体。本研究的目的是使用体内小动物正电子发射断层扫描（PET）成像（微型PET）研究4 - 硼代 - 2 - [（18）F] - 氟 - L - 苯丙氨酸 - 果糖（[（18）F]FBPA - F）在脑内注射胶质瘤的大鼠中的情况。将左脑患有F98胶质瘤的雄性Fischer 344大鼠用于这些研究。在肿瘤接种后第13天对[（18）F]FBPA - F进行动态PET成像。进行动脉采血以获得示踪剂动力学建模的输入函数。[（18）F]FBPA - F在胶质瘤与正常脑之间的积累率接近3。BPA - F和[（18）F]FBPA - F的摄取特征相似。结果表明，BPA - F注射后4小时将是BNCT的最佳照射时间。使用三室模型估计速率常数。本研究为BNCT在脑肿瘤患者中的临床应用提供了有用信息。