Zagorchev Lyubomir, Mulligan-Kehoe Mary J
Angiogenesis Research Center, Dartmouth Medical School, Lebanon, NH 03756, USA.
Eur J Radiol. 2009 May;70(2):305-11. doi: 10.1016/j.ejrad.2009.01.053.
Vascular imaging of angiogenesis in mouse models of disease requires multi modal imaging hardware capable of targeting both structure and function at different physical scales. The three dimensional (3D) structure and function vascular information allows for accurate differentiation between biological processes. For example, image analysis of vessel development in angiogenesis vs. arteriogenesis enables more accurate detection of biological variation between subjects and more robust and reliable diagnosis of disease. In the recent years a number of micro imaging modalities have emerged in the field as preferred means for this purpose. They provide 3D volumetric data suitable for analysis, quantification, validation, and visualization of results in animal models. This review highlights the capabilities of microCT, ultrasound and microPET for multimodal imaging of angiogenesis and molecular vascular targets in a mouse model of tumor angiogenesis. The basic principles of the imaging modalities are described and experimental results are presented.
在疾病小鼠模型中对血管生成进行血管成像需要多模态成像硬件，该硬件能够在不同物理尺度上针对结构和功能。三维（3D）结构和功能血管信息有助于准确区分生物过程。例如，对血管生成与动脉生成过程中血管发育的图像分析能够更准确地检测个体间的生物差异，并对疾病进行更稳健可靠的诊断。近年来，该领域出现了许多显微成像模态，作为实现这一目的的首选手段。它们提供适用于动物模型中结果分析、量化、验证和可视化的3D体积数据。本综述重点介绍了微型计算机断层扫描（microCT）、超声和微型正电子发射断层扫描（microPET）在肿瘤血管生成小鼠模型中对血管生成和分子血管靶点进行多模态成像的能力。描述了成像模态的基本原理并展示了实验结果。
