生存素在胰腺癌中的表达及其与Bcl-2表达的相关性。
Expression of Survivin in pancreatic cancer and its correlation to expression of Bcl-2.
作者信息
Qiao Jian-Guo, Zhang Yu-Qing, Yin Yu-Chun, Tan Zui
机构信息
Department of General Surgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, China.
出版信息
World J Gastroenterol. 2004 Sep 15;10(18):2759-61. doi: 10.3748/wjg.v10.i18.2759.
AIM
To investigate the expression of Survivin in pancreatic cancer and its correlation to the expression of Bcl-2.
METHODS
Survivin and Bcl-2 expressions were examined by immunohistochemistry in 42 tissue samples from pancreatic cancer and 10 from normal pancrease.
RESULTS
No survivin expression was detected in the tissue samples from normal pancrease, while it was detected in 34 of 42 tissue samples from pancreatic cancer (81.95%). There was a correlation between survivin expression and differentiation and stages of pancreatic cancer. Survivin positive cases were strongly correlated to Bcl-2 expression (28/30 vs 6/12, P<0.05).
CONCLUSION
Overexpression of survivin plays an important role in the development and progression of pancreatic cancer, and correlates to the expression of Bcl-2. Survivin expression can be used as a prognostic factor.
目的
探讨生存素（Survivin）在胰腺癌中的表达及其与Bcl-2表达的相关性。
方法
采用免疫组织化学法检测42例胰腺癌组织样本和10例正常胰腺组织样本中Survivin和Bcl-2的表达。
结果
正常胰腺组织样本中未检测到Survivin表达，而42例胰腺癌组织样本中有34例检测到Survivin表达（81.95%）。Survivin表达与胰腺癌的分化程度和分期相关。Survivin阳性病例与Bcl-2表达密切相关（28/30 vs 6/12，P<0.05）。
结论
Survivin的过表达在胰腺癌的发生发展中起重要作用，且与Bcl-2表达相关。Survivin表达可作为一个预后因素。
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