Altieri Dario C
Department of Cancer Biology, LRB-428, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA.
Nat Rev Cancer. 2003 Jan;3(1):46-54. doi: 10.1038/nrc968.
Acquisition of the ability to evade cellular suicide, or apoptosis, is one of the master switches that contributes to cellular transformation and, ultimately, to invasive cancer. Much has been learned about the molecular organization of apoptotic pathways and their regulators, but the identification and validation of translational targets for apoptosis-based cancer therapy has posed a great challenge. Survivin is an attractive candidate for cancer therapy, so what is its potential applicability in the clinic?
获得逃避细胞自杀（即细胞凋亡）的能力是促成细胞转化并最终导致侵袭性癌症的主要转变之一。关于凋亡途径及其调节因子的分子组织，我们已经了解了很多，但基于凋亡的癌症治疗的转化靶点的识别和验证带来了巨大挑战。生存素是癌症治疗的一个有吸引力的候选靶点，那么它在临床上的潜在适用性如何呢？
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