Lange E M, Chen H, Brierley K, Livermore H, Wojno K J, Langefeld C D, Lange K, Cooney K A
Department of Biostatistics, University of Michigan, Ann Arbor 48105, USA.
Cancer Epidemiol Biomarkers Prev. 2000 Apr;9(4):439-42.
Recent studies have provided epidemiological evidence in support of a possible prostate cancer susceptibility locus on the X chromosome. The androgen receptor (AR) gene, located at Xq11-12, has been implicated as a risk factor for the development of prostate cancer. To examine the potential role of the AR locus in prostate cancer susceptibility, the AR CAG repeat length was measured in 270 Caucasian men with prostate cancer from 133 unrelated families. Each of these families has two or more confirmed cases of prostate cancer occurring in first- and/or second-degree relatives. No evidence for linkage of the AR gene to prostate cancer was observed. We tested for the previously reported association of short CAG alleles with prostate cancer using t tests, Pearson's chi2 tests, and logistic regression; analyses were subsequently repeated to incorporate only men with moderate- to high-grade prostate cancer. No association between AR CAG allele length and prostate cancer was detected when either a subset of unrelated patients or a subset of unrelated patients with moderate- to high-grade cancer was compared with a set of unrelated controls. We failed to detect an association between short AR CAG alleles and early age of prostate cancer diagnosis. Once specific hereditary prostate cancer genes have been identified, future studies can more carefully delineate the potential role of this AR polymorphism as a modifier locus in high-risk families.
近期研究提供了流行病学证据，支持X染色体上可能存在前列腺癌易感基因座。位于Xq11 - 12的雄激素受体（AR）基因被认为是前列腺癌发生的一个风险因素。为了研究AR基因座在前列腺癌易感性中的潜在作用，我们检测了来自133个无亲缘关系家庭的270名患有前列腺癌的白种男性的AR CAG重复序列长度。这些家庭中的每一个都有两个或更多在一级和/或二级亲属中确诊的前列腺癌病例。未观察到AR基因与前列腺癌存在连锁关系。我们使用t检验、Pearson卡方检验和逻辑回归分析了先前报道的短CAG等位基因与前列腺癌的相关性；随后仅纳入中高级别前列腺癌患者重复进行分析。当将无亲缘关系患者的一个子集或无亲缘关系的中高级别癌症患者的一个子集与一组无亲缘关系的对照进行比较时，未检测到AR CAG等位基因长度与前列腺癌之间存在关联。我们未检测到短AR CAG等位基因与前列腺癌早期诊断之间存在关联。一旦确定了特定的遗传性前列腺癌基因，未来的研究就可以更仔细地描绘这种AR多态性作为高危家庭中修饰基因座的潜在作用。
