Kalueff A V, Eremin K O, Tuohimaa P
Center of Physiology and Biochemical Research, Kiev 01042, Ukraine.
Biochemistry (Mosc). 2004 Jul;69(7):738-41. doi: 10.1023/b:biry.0000040196.65686.2f.
This review considers modern data on the mechanisms underlying the neuroprotective effect of the neurosteroid vitamin D(3) and its receptors in the nervous system. Special attention is paid to Ca2+ regulation, stimulation of neurotrophin release, interaction with reactive oxygen and nitrogen species, and neuroimmunomodulatory effects of calcitriol, the main biologically active form of vitamin D(3), in the nervous system.
