Biercewicz Monika, Kwiatkowska Katarzyna, Kędziora-Kornatowska Kornelia, Krintus Magdalena, Ślusarz Robert, Ruszkowska-Ciastek Barbara
Department of Geriatrics, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.
Department of Pathophysiology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.
J Clin Med. 2023 Mar 19;12(6):2370. doi: 10.3390/jcm12062370.
Vitamin D deficiency is an important issue in the worldwide population, especially in older people. According to the World Health Organization data, in 2030, 1 in 6 people in the world will be 60 years old or older. The main storage site for vitamin D is adipose tissue. Further, 25(OH)D regulates the expression of adipogenic genes and apoptosis of adipocytes and directly influences the secretion of the appetite-regulating hormone-leptin. Thus, we investigated the impact of the serum concentrations of leptin, adiponectin, omentin, ghrelin, visfatin, and biochemical parameters on vitamin D and estimated glomerular filtration rate (eGFR) in geriatric females. Our studies indicate that the leptin, visfatin and ghrelin are linked with vitamin D concentration and the eGFR rate in the geriatric females. (1) Background: Vitamin D deficiency is common in older people, and researchers are looking for a link between vitamin D deficiency and the occurrence of diseases in advanced age. The study aimed to evaluate the association between serum 25(OH)D levels and clinical variables in older females. (2) Methods: We investigated the impact of the serum concentrations of leptin, adiponectin, omentin, ghrelin, visfatin, and biochemical parameters on vitamin D and estimated the glomerular filtration rate (eGFR) in 74 geriatric females. (3) Results: We observed a significantly higher concentration of creatinine and visfatin in the G2 stage (eGFR = 60-89 mL/min./1.73 m). We performed an additional analysis to exclude the effect of vitamin D supplementation and obtained a significantly higher vitamin D concentration in the G2 stage. We found significantly lower vitamin D concentrations in older people. In addition, in a person with low levels of vitamin D, we observed significantly lower levels of albumin and ghrelin. Older patients (80 to 89 years old) had significantly lower levels of vitamin D, albumin, insulin, HOMA-IR, and ghrelin than younger patients (60 to 69 years old). Spearman's correlations performed to examine the relationship between clinical variables seemed to confirm previous results. According to ROC curve analysis, leptin concentration was the strongest predictor of vitamin D fluctuations (the area under the curve, AUC = 0.685; with 79.5% sensitivity and 51.4% specificity; = 0.0291). However, visfatin reached the most accurate AUC = 0.651 with 84.2% sensitivity and 49.1% specificity for predicting effects on eGFR. (4) Conclusions: The results suggest that serum levels of leptin, visfatin, and ghrelin are linked with vitamin D concentration and the eGFR rate in the population of geriatric females.
维生素D缺乏是全球人口中的一个重要问题，尤其是在老年人中。根据世界卫生组织的数据，到2030年，世界上每6人中就有1人年龄在60岁及以上。维生素D的主要储存部位是脂肪组织。此外，25(OH)D调节脂肪生成基因的表达和脂肪细胞的凋亡，并直接影响食欲调节激素瘦素的分泌。因此，我们研究了瘦素、脂联素、网膜素、胃饥饿素、内脂素的血清浓度以及生化参数对老年女性维生素D和估算肾小球滤过率（eGFR）的影响。我们的研究表明，瘦素、内脂素和胃饥饿素与老年女性的维生素D浓度和eGFR率有关。（1）背景：维生素D缺乏在老年人中很常见，研究人员正在寻找维生素D缺乏与老年疾病发生之间的联系。该研究旨在评估老年女性血清25(OH)D水平与临床变量之间的关联。（2）方法：我们研究了74名老年女性血清中瘦素、脂联素、网膜素、胃饥饿素、内脂素的浓度以及生化参数对维生素D的影响，并估算了肾小球滤过率（eGFR）。（3）结果：我们观察到G2期（eGFR = 60 - 89 mL/min./1.73 m²）肌酐和内脂素的浓度显著更高。我们进行了额外的分析以排除维生素D补充的影响，结果发现G2期维生素D浓度显著更高。我们发现老年人的维生素D浓度显著更低。此外，在维生素D水平低的人群中，我们观察到白蛋白和胃饥饿素水平显著更低。老年患者（80至89岁）的维生素D、白蛋白、胰岛素水平、胰岛素抵抗指数（HOMA-IR）和胃饥饿素水平显著低于年轻患者（60至69岁）。为检验临床变量之间的关系而进行的斯皮尔曼相关性分析似乎证实了先前的结果。根据ROC曲线分析，瘦素浓度是维生素D波动的最强预测指标（曲线下面积，AUC = 0.685；灵敏度为79.5%，特异性为51.4%；P = 0.0291）。然而，对于预测对eGFR的影响，内脂素的AUC最为准确，为0.651，灵敏度为84.2%，特异性为49.1%。（4）结论：结果表明，在老年女性人群中，血清瘦素、内脂素和胃饥饿素水平与维生素D浓度和eGFR率有关。
