Lakadamyali Melike, Rust Michael J, Zhuang Xiaowei
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street Naito Building, Cambridge, MA 02138, USA.
Microbes Infect. 2004 Aug;6(10):929-36. doi: 10.1016/j.micinf.2004.05.002.
Receptor-mediated endocytosis is known to play an important role in the entry of many viruses into host cells. However, the exact internalization mechanism has, until recently, remained poorly understood for many medically important viruses, including influenza. Developments in real-time imaging of single viruses as well as the use of dominant-negative mutants to selectively block specific endocytic pathways have improved our understanding of the influenza infection process.
已知受体介导的内吞作用在许多病毒进入宿主细胞的过程中发挥重要作用。然而，直到最近，对于包括流感病毒在内的许多具有医学重要性的病毒，其确切的内化机制仍知之甚少。单病毒实时成像技术的发展以及利用显性负性突变体选择性阻断特定内吞途径的方法，增进了我们对流感感染过程的理解。
