Bonnet M H, Arand D L
Dayton VA Hospital, Wright State University, and Kettering Medical Center, Dayton, OH 45428, USA.
Sleep Med Rev. 1997 Dec;1(2):97-108. doi: 10.1016/s1087-0792(97)90012-5.
Primary or psychophysiological insomnia has alternatively been viewed as either a predominantly psychological problem or as a predominantly physiological problem. Several early studies of patients were not able to document physiological differences, but more recent studies have found that many patients with primary insomnia take longer than control subjects to fall asleep on daytime nap tests despite feeling fatigued and they have elevated metabolic rate throughout both night and day. Other recent studies have found that increasing physiological arousal level for a week in normal sleepers produced the major secondary symptoms reported by insomniacs. In contrast, producing the disturbed sleep of insomniacs in a group of normal sleepers did not produce the typical pattern of secondary symptoms. Taken together, evidence is presented which supports the contention that primary insomniacs suffer from a disorder of hyperarousal and that the elevated arousal produces the poor sleep and other symptoms reported by patients. It is therefore suggested that new treatment strategies directed at reduction of arousal level be considered in these patients.
原发性失眠或心理生理性失眠,要么被视为主要是心理问题,要么被视为主要是生理问题。早期对患者的几项研究未能证明生理差异,但最近的研究发现,许多原发性失眠患者在白天小睡测试中入睡时间比对照组更长,尽管感到疲劳,而且他们在白天和夜间的代谢率都有所升高。其他近期研究发现,正常睡眠者连续一周提高生理唤醒水平会产生失眠患者报告的主要继发性症状。相比之下,在一组正常睡眠者中造成失眠患者的睡眠障碍,并未产生典型的继发性症状模式。综合来看,现有证据支持这样的观点,即原发性失眠患者患有高唤醒障碍,而升高的唤醒水平导致了患者报告的睡眠不佳和其他症状。因此,建议针对这些患者考虑采用旨在降低唤醒水平的新治疗策略。