Integrative Medicine Nutrition Department, ADS Vitality B.V., 2517 AS The Hague, The Netherlands.
Department of Experimental Oncology, European Institute of Oncology IRCCS, 20139 Milano, Italy.
Nutrients. 2024 Jan 29;16(3):390. doi: 10.3390/nu16030390.
Over recent decades, a growing body of evidence has emerged linking the composition of the gut microbiota to sleep regulation. Interestingly, the prevalence of sleep disorders is commonly related to cardiometabolic comorbidities such as diabetes, impaired lipid metabolism, and metabolic syndrome (MetS). In this complex scenario, the role of the gut-brain axis as the main communicating pathway between gut microbiota and sleep regulation pathways in the brain reveals some common host-microbial biomarkers in both sleep disturbances and MetS. As the biological mechanisms behind this complex interacting network of neuroendocrine, immune, and metabolic pathways are not fully understood yet, the present systematic review aims to describe common microbial features between these two unrelated chronic conditions.
This systematic review highlights a total of 36 articles associating the gut microbial signature with MetS or sleep disorders. Specific emphasis is given to studies evaluating the effect of dietary patterns, dietary supplementation, and probiotics on MetS or sleep disturbances.
Dietary choices promote microbial composition and metabolites, causing both the amelioration and impairment of MetS and sleep homeostasis.
近几十年来，越来越多的证据表明肠道微生物群的组成与睡眠调节有关。有趣的是，睡眠障碍的流行通常与代谢合并症有关，如糖尿病、脂质代谢受损和代谢综合征（MetS）。在这种复杂的情况下，肠道-大脑轴作为肠道微生物群和大脑中睡眠调节途径之间的主要通讯途径，揭示了睡眠障碍和 MetS 中一些常见的宿主-微生物生物标志物。由于这个复杂的神经内分泌、免疫和代谢途径相互作用网络的生物学机制尚未完全理解，本系统综述旨在描述这两种不相关的慢性疾病之间的常见微生物特征。
本系统综述共强调了 36 篇将肠道微生物特征与 MetS 或睡眠障碍相关联的文章。特别强调了评估饮食模式、饮食补充和益生菌对 MetS 或睡眠障碍影响的研究。
饮食选择促进了微生物组成和代谢物的产生，从而改善和损害 MetS 和睡眠稳态。
