Łuszczek Wioleta, Mańczak Maria, Cisło Maria, Nockowski Piotr, Wiśniewski Andrzej, Jasek Monika, Kuśnierczyk Piotr
Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Hum Immunol. 2004 Jul;65(7):758-66. doi: 10.1016/j.humimm.2004.05.008.
Psoriasis vulgaris, particularly its juvenile form, is strongly associated with the HLA-Cw06 allele encoding the HLA-Cw6 molecule. This molecule is recognized by the inhibitory receptor KIR2DL1 and the activatory receptor KIR2DS1, which are expressed on natural killer cells and subpopulations of T lymphocytes. Humans differ by the presence or absence of particular KIR genes. We hypothesized that either activatory KIR2DS1 or inhibitory KIR2DL1 gene frequencies might be different in psoriatic patients from a control population. Therefore, we compared the frequencies of KIR2D inhibitory (L) and activatory (S) genes in 116 psoriasis vulgaris patients and in 123 healthy controls. Fourteen novel gene combinations were found. KIR2DS1 was present in 85% of the patients, but only in 51% of the controls (corrected p [pc] < 0.0009). Similarly, HLA-Cw06 was much more frequent in patients (77%) than in controls (17%; pc < 0.00002). Statistical analysis suggests that, although the contribution of these two factors to psoriasis is partially independent, they interact nevertheless. This result strongly speaks for a role of KIR2DS1 on recognition of HLA-Cw6 in susceptibility to psoriasis.
寻常型银屑病，尤其是其青少年型，与编码HLA - Cw6分子的HLA - Cw06等位基因密切相关。该分子可被抑制性受体KIR2DL1和激活性受体KIR2DS1识别，这两种受体在自然杀伤细胞和T淋巴细胞亚群上表达。人类因特定KIR基因的有无而存在差异。我们推测，在银屑病患者中，激活性KIR2DS1基因或抑制性KIR2DL1基因的频率可能与对照组不同。因此，我们比较了116例寻常型银屑病患者和123例健康对照者中KIR2D抑制性（L）基因和激活性（S）基因的频率。发现了14种新的基因组合。KIR2DS1在85%的患者中存在，而在对照组中仅为51%（校正P值[pc]<0.0009）。同样，HLA - Cw06在患者中的频率（77%）远高于对照组（17%；pc<0.00002）。统计分析表明，尽管这两个因素对银屑病的影响部分独立，但它们仍相互作用。这一结果有力地证明了KIR2DS1在识别HLA - Cw6对银屑病易感性中的作用。
