Williams Fionnuala, Meenagh Ashley, Sleator Carole, Cook Daniel, Fernandez-Vina Marcelo, Bowcock Anne M, Middleton Derek
Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland.
Hum Immunol. 2005 Jul;66(7):836-41. doi: 10.1016/j.humimm.2005.04.005.
Killer cell immunoglobulin-like receptor genotyping was performed on a cohort of American Caucasian patients with psoriasis to investigate any possible relationship between these chromosome 19 genes and autoimmune-linked disease. This patient cohort also contained a subgroup of patients who had been additionally diagnosed as positive for psoriatic arthritis (PsA). Because of the known association of human leucocyte antigen (HLA)-Cw*06 with psoriasis, the study concentrated on the five KIR genes that have HLA-C as their recognized ligand (i.e., KIR2DL1, -2DL2, -2DL3, -2DS1, and -2DS2). An increase in the frequency of the activating KIR2DS1 gene was detected in the PsA patients, compared with psoriasis patients negative for PsA and an unaffected American Caucasian control group.
对一组美国白种人银屑病患者进行了杀伤细胞免疫球蛋白样受体基因分型，以研究这些19号染色体基因与自身免疫性相关疾病之间的任何可能关系。该患者队列还包含一个亚组，这些患者还被额外诊断为银屑病关节炎（PsA）阳性。由于已知人类白细胞抗原（HLA）-Cw*06与银屑病有关联，该研究集中于五个以HLA-C作为其公认配体的KIR基因（即KIR2DL1、-2DL2、-2DL3、-2DS1和-2DS2）。与PsA阴性的银屑病患者和未受影响的美国白种人对照组相比，在PsA患者中检测到激活型KIR2DS1基因的频率增加。
