Kurosaki T, Gander I, Wirthmueller U, Ravetch J V
DeWitt Wallace Research Laboratory, Sloan-Kettering Institute, New York, New York 10021.
J Exp Med. 1992 Feb 1;175(2):447-51. doi: 10.1084/jem.175.2.447.
Fc epsilon RI is a tetrameric receptor, composed of a ligand recognition subunit, alpha, a beta chain, and dimeric gamma chains. Previous studies have indicated that the dimeric gamma chain is associated with Fc gamma RIIIA (CD16) on natural killer cells and macrophages as well as the clonotypic T cell receptor. Here we show that in mast cells, in addition to the dimeric gamma chains, the beta subunit is associated not only with Fc epsilon RI, but also with Fc gamma RIIIA. Functional reconstitution studies with a mastocytoma cell line indicate that Fc gamma RIIIA composed of alpha, beta, and gamma subunits has the capacity for signal transduction. These studies suggest that through the association of alternative ligand recognition subunits (alpha epsilon, alpha gamma), a common signal transduction complex (beta gamma 2) mediates similar biochemical and effector functions in response to immunoglobulin G (IgG) and IgE.
FcεRI是一种四聚体受体，由一个配体识别亚基α、一条β链和二聚体γ链组成。先前的研究表明，二聚体γ链与自然杀伤细胞和巨噬细胞上的FcγRIIIA（CD16）以及克隆型T细胞受体相关。在这里我们表明，在肥大细胞中，除了二聚体γ链外，β亚基不仅与FcεRI相关，还与FcγRIIIA相关。用肥大细胞瘤细胞系进行的功能重建研究表明，由α、β和γ亚基组成的FcγRIIIA具有信号转导能力。这些研究表明，通过替代配体识别亚基（αε、αγ）的关联，一个共同的信号转导复合物（βγ2）介导了对免疫球蛋白G（IgG）和IgE的类似生化和效应功能。
