对两个编码B淋巴细胞抗原CD20（B1、Bp35）的cDNA克隆的分析，CD20是一种III型整合膜蛋白。
Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III integral membrane protein.
作者信息
Stamenkovic I, Seed B
机构信息
Department of Genetics, Harvard Medical School, Boston, Massachusetts.
出版信息
J Exp Med. 1988 Jun 1;167(6):1975-80. doi: 10.1084/jem.167.6.1975.
Abstract
Two cDNA clones encoding the pan-B cell CD20 antigen were isolated from a COS cell expression library. The two clones bear identical coding sequences and differ only in the length of the 3' untranslated region. The predicted CD20 sequence is 297 residues long and contains three hydrophobic domains, one of which is long enough to span the membrane twice. COS cells transfected with either CD20 clone express an immunoreactive protein of 33 kD.
摘要
从COS细胞表达文库中分离出两个编码泛B细胞CD20抗原的cDNA克隆。这两个克隆具有相同的编码序列，只是3'非翻译区的长度不同。预测的CD20序列长297个氨基酸残基，包含三个疏水结构域，其中一个足够长，可以跨膜两次。用任一CD20克隆转染的COS细胞表达一种33kD的免疫反应性蛋白。
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