Christopherson Kent W, Hangoc Giao, Mantel Charlie R, Broxmeyer Hal E
Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Science. 2004 Aug 13;305(5686):1000-3. doi: 10.1126/science.1097071.
Hematopoietic stem cell homing and engraftment are crucial to transplantation efficiency, and clinical engraftment is severely compromised when donor-cell numbers are limiting. The peptidase CD26 (DPPIV/dipeptidylpeptidase IV) removes dipeptides from the amino terminus of proteins. We present evidence that endogenous CD26 expression on donor cells negatively regulates homing and engraftment. By inhibition or deletion of CD26, it was possible to increase greatly the efficiency of transplantation. These results suggest that hematopoietic stem cell engraftment is not absolute, as previously suggested, and indicate that improvement of bone marrow transplant efficiency may be possible in the clinic.
造血干细胞归巢和植入对移植效率至关重要，当供体细胞数量有限时，临床植入会严重受损。肽酶CD26（二肽基肽酶IV）从蛋白质的氨基末端去除二肽。我们提供的证据表明，供体细胞上的内源性CD26表达对归巢和植入具有负调节作用。通过抑制或缺失CD26，可以大大提高移植效率。这些结果表明，造血干细胞植入并非如先前认为的那样是绝对的，并且表明在临床上提高骨髓移植效率是可能的。
