Chen Ming, Yang Beibei, Zhang Xing
Department of Otolaryngology, Second Affiliated Hospital of Medical School, Zhejiang University, Hangzhou, 310009, China.
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2004 May;18(5):286-7.
To investigate telomerase activity in laryngeal nonmalignant mucosa adjacent to carcinoma and discuss its effect on extension and recurrence of laryngeal carcinoma.
Telomerase repeat amplification protocol was used and combined with histological examination.
The positive percentage of telomerase activation was even higher in laryngeal nonmalignant mucosa distant toward surgically negative margin of carcinoma than in laryngeal carcinomas themselves (P<0.05).
Telomerase activation occurred probably before the morphologic alteration, which may imply expansion of the cells with potential of malignant transformation.
