Gołabek W, Szyszko J
Clin Otolaryngol Allied Sci. 1984 Feb;9(1):9-13. doi: 10.1111/j.1365-2273.1984.tb01466.x.
The total lactate dehydrogenase (LDH) activity and LDH isoenzyme pattern were measured in tissue taken from laryngeal cancers and from the laryngeal mucosa both close to and distant from the tumour margin. An increase in the total LDH activity and a cathodic shift in the isoenzyme pattern were found in tumour tissue compared to the close and distant mucosa. However, significant LDH alterations in the mucosa close to the tumour were shown in comparison to the distant mucosa and to the laryngeal mucosa of controls. Histochemical studies showed the LDH activity to be located in the basal and parabasal layers of the epithelium and in the cancer foci.
对取自喉癌以及肿瘤边缘近处和远处的喉黏膜组织进行了总乳酸脱氢酶（LDH）活性和LDH同工酶谱的检测。与近处和远处的黏膜相比，肿瘤组织中总LDH活性增加，同工酶谱向阴极偏移。然而，与远处黏膜及对照组的喉黏膜相比，肿瘤近处黏膜的LDH有显著改变。组织化学研究显示，LDH活性位于上皮的基底层和副基底层以及癌灶中。
