Lacut Karine, Oger Emmanuel, Le Gal Grégoire, Couturaud Francis, Louis Stéphanie, Leroyer Christophe, Mottier Dominique
Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Department of Internal Medicine and Chest Diseases, Hôpital de la Cavale Blanche, 29609 Brest Cedex, France.
Fundam Clin Pharmacol. 2004 Aug;18(4):477-82. doi: 10.1111/j.1472-8206.2004.00252.x.
Previous studies of selected patients have suggested a reduction in the risk of venous thromboembolism with the use of statins. The objective of this study is to evaluate the influence of statin use on the risk of venous thromboembolic (VTE) events. The study is a case-control study (EDITH: Etude des Déterminants et Interactions de la Thrombose Veineuse), designed to investigate the genetic and environmental risk factors of VTE. A total of 377 patients consecutively hospitalized in the Brest University Hospital for a documented VTE event, between May 2000 and May 2002, and 377 age- and sex-matched controls were studied. Statin use was associated with a 58% decreased risk of VTE [odds ratio (OR) 0.42; 95% confidence interval (CI) 0.23-0.76; P = 0.002]. Adjustment for age, gender, coronary heart disease, atherosclerothrombotic disease or current use of aspirin did not alter the result. Neither fibrates (OR 1.38; 95% CI 0.76-2.52; P = 0.26), nor thienopyridines (OR 1.07; 95% CI 0.48-2.41; P = 0.85) were associated with a reduced risk of VTE. Aspirin use tended to decrease the risk of VTE, but this result was not significant (OR, 0.66; 95% CI, 0.42-1.05). The use of statins is associated with a significant reduction in the risk of VTE, irrespective of age, gender, and past history of atherosclerothrombotic disease, as well as the use of aspirin. This possible protective effect of statins warrants further investigations.
之前针对特定患者的研究表明，使用他汀类药物可降低静脉血栓栓塞的风险。本研究的目的是评估他汀类药物的使用对静脉血栓栓塞（VTE）事件风险的影响。该研究是一项病例对照研究（EDITH：静脉血栓形成的决定因素与相互作用研究），旨在调查VTE的遗传和环境风险因素。对2000年5月至2002年5月期间在布雷斯特大学医院因确诊VTE事件而连续住院的377例患者，以及377例年龄和性别匹配的对照进行了研究。使用他汀类药物与VTE风险降低58%相关[比值比（OR）0.42；95%置信区间（CI）0.23 - 0.76；P = 0.002]。对年龄、性别、冠心病、动脉粥样硬化血栓形成疾病或当前使用阿司匹林进行调整后，结果未改变。贝特类药物（OR 1.38；95% CI 0.76 - 2.52；P = 0.26）和噻吩并吡啶类药物（OR 1.07；95% CI 0.48 - 2.41；P = 0.85）均与VTE风险降低无关。使用阿司匹林有降低VTE风险的趋势，但这一结果不显著（OR，0.66；95% CI，0.42 - 1.05）。无论年龄、性别、动脉粥样硬化血栓形成疾病史以及是否使用阿司匹林，使用他汀类药物均与VTE风险显著降低相关。他汀类药物这种可能的保护作用值得进一步研究。
