Deparment of Vascular Medicine, University Paris Decartes and INSERM U765, Paris, France.
Thromb Haemost. 2009 Dec;102(6):1259-64. doi: 10.1160/TH09-04-0222.
Influenza vaccination can reduce the risk of cardiovascular events in patients with coronary heart disease, but its impact on the risk of venous thromboembolism (VTE) has not been studied. It was the aim of this study to investigate whether influenza vaccination reduces the risk of VTE. We conducted a case-control study involving 1,454 adults enrolled in 11 French centers between 2003 and 2007, comprising 727 consecutive cases with a first documented episode of VTE and 727 age- and sex-matched controls. In the case and control groups 202 (28.2%) and 233 (32.1%) subjects, respectively, had been vaccinated against influenza during the previous 12 months. After multivariate regression analysis, the odds ratios (OR) for VTE associated with vaccination were 0.74 (95% confidence interval [CI], 0.57-0.97) and 0.52 (95% CI, 0.32-0.85), respectively, for the whole population and for subjects aged 52 years or less. The protective effect of vaccination was similar for deep venous thrombosis (OR 0.9, 95% CI, 0.60-1.35) and pulmonary embolism (OR 0.71, 95% CI, 0.53-0.94) and for both provoked (OR 0.71, 95% CI, 0.53-0.97) and unprovoked VTE (OR 0.85, 95% CI, 0.59-1.23). This case-control study suggests that influenza vaccination is associated with a reduced risk of VTE.
流感疫苗接种可降低冠心病患者发生心血管事件的风险，但尚未研究其对静脉血栓栓塞症（VTE）风险的影响。本研究旨在探讨流感疫苗接种是否可降低 VTE 的风险。我们开展了一项病例对照研究，纳入了 2003 年至 2007 年期间在法国 11 个中心登记的 1454 例成年人，其中包括 727 例连续确诊的首次 VTE 患者和 727 例年龄和性别匹配的对照者。在病例组和对照组中，分别有 202（28.2%）例和 233（32.1%）例在过去 12 个月中接种了流感疫苗。多变量回归分析显示，接种疫苗与 VTE 的比值比（OR）分别为 0.74（95%可信区间[CI]，0.57-0.97）和 0.52（95% CI，0.32-0.85），全人群和年龄≤52 岁者的结果相似。疫苗接种对深静脉血栓形成（OR 0.9，95% CI，0.60-1.35）和肺栓塞（OR 0.71，95% CI，0.53-0.94）的保护作用相似，对有诱因（OR 0.71，95% CI，0.53-0.97）和无诱因 VTE（OR 0.85，95% CI，0.59-1.23）的保护作用也相似。本病例对照研究表明，流感疫苗接种与 VTE 风险降低相关。
