低密度脂蛋白胆固醇水平是否会调节多巴胺D4受体基因（DRD4）与寻求新奇之间的关系？

Does the level of LDL cholesterol moderate a relationship between DRD4 and novelty seeking?

作者信息

Elovainio Marko, Kivimäki Mika, Puttonen Sampsa, Heponiemi Tarja, Keltikangas-Järvinen Liisa, Viikari Jorma

机构信息

Department of Psychology, PO Box 9, University of Helsinki, FIN 00014 Helsinki, Finland.

出版信息

Biol Psychol. 2005 Jan;68(1):79-86. doi: 10.1016/j.biopsycho.2004.03.017.

DOI:10.1016/j.biopsycho.2004.03.017

PMID:15312696

Abstract

This study examined the role of low density lipoprotein (LDL) cholesterol level in the association between Dopamine D4 receptor (DRD4) polymorphism and temperament dimension novelty seeking. From the on-going population based study of "Cardiovascular Risk in Young Finns", 78 men and women responded to the novelty seeking scale of the temperament and character inventory [Archives of General Psychiatry 44 (1987) 573] and were apolipoprotein E (apoE) and DRD4 genotyped. DRD4 polymorphism was related to disorderliness, a component of novelty seeking, in subjects with high LDL cholesterol level but not in subjects with low LDL cholesterol level. This finding did not change after adjustment for apoE polymorphism. Our findings suggest that the genetic determination of temperament may be dependent on biological factors, such as LDL cholesterol.

摘要

本研究探讨了低密度脂蛋白（LDL）胆固醇水平在多巴胺D4受体（DRD4）基因多态性与气质维度寻求新奇之间关联中的作用。在正在进行的基于人群的“年轻芬兰人心血管风险”研究中，78名男性和女性对气质与性格量表中的寻求新奇分量表[《普通精神病学文献》44（1987）573]做出了回应，并进行了载脂蛋白E（apoE）和DRD4基因分型。DRD4基因多态性与寻求新奇的一个组成部分——无序性相关，但仅存在于LDL胆固醇水平高的受试者中，而在LDL胆固醇水平低的受试者中则无此关联。在对apoE基因多态性进行校正后，这一发现并未改变。我们的研究结果表明，气质的遗传决定可能依赖于生物因素，如LDL胆固醇。