Ono Y, Manki H, Yoshimura K, Muramatsu T, Mizushima H, Higuchi S, Yagi G, Kanba S, Asai M
Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Am J Med Genet. 1997 Sep 19;74(5):501-3.
This study was designed to assess the association between novelty seeking and D4DR gene polymorphism in the Japanese population. The 48 bp repeat polymorphism in the third exon of the dopamine D4 receptor gene of 153 normal female students was correlated with personality feature results from the Japanese version of Cloninger's Temperament and Character Inventory. The Novelty Seeking subscale of Exploratory Excitability had a significant association with long alleles of the polymorphic exon III repeat sequence of D4DR. Our results suggest that there is an association between long alleles of the polymorphic exon III repeat sequence of D4DR and the personality traits of the Novelty Seeking subscale of Exploratory Excitability, regardless of racial differences in the frequencies of D4DR exon III repeat polymorphism.
本研究旨在评估日本人群中寻求新奇与D4DR基因多态性之间的关联。对153名正常女学生多巴胺D4受体基因第三外显子的48bp重复多态性与日本版克隆宁格气质性格量表的人格特征结果进行了相关性分析。探索性兴奋性的寻求新奇分量表与D4DR多态性外显子III重复序列的长等位基因存在显著关联。我们的结果表明，无论D4DR外显子III重复多态性频率存在种族差异，D4DR多态性外显子III重复序列的长等位基因与探索性兴奋性寻求新奇分量表的人格特质之间都存在关联。
