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烟酰胺治疗早发性糖尿病的双盲随机试验

Double-blind randomized trial of nicotinamide on early-onset diabetes.

作者信息

Lewis C M, Canafax D M, Sprafka J M, Barbosa J J

机构信息

Department of Medicine, School of Medicine, College of Pharmacy, University of Minnesota, Minneapolis 55455.

出版信息

Diabetes Care. 1992 Jan;15(1):121-3. doi: 10.2337/diacare.15.1.121.

DOI:10.2337/diacare.15.1.121
PMID:1531328
Abstract

OBJECTIVE

To determine the efficacy of nicotinamide in inducing remission in early-onset insulin-dependent diabetes mellitus.

RESEARCH DESIGN AND METHODS

This study was a double-blind, randomized clinical trial.

CONCLUSIONS

Nicotinamide failed to induce remission or differences on beta-cell secretion between the two groups.

摘要

目的

确定烟酰胺诱导早发型胰岛素依赖型糖尿病缓解的疗效。

研究设计与方法

本研究为双盲随机临床试验。

结论

烟酰胺未能诱导缓解，两组间β细胞分泌也无差异。

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1
Double-blind randomized trial of nicotinamide on early-onset diabetes.烟酰胺治疗早发性糖尿病的双盲随机试验
Diabetes Care. 1992 Jan;15(1):121-3. doi: 10.2337/diacare.15.1.121.
2
A trial of nicotinamide in newly diagnosed patients with type 1 (insulin-dependent) diabetes mellitus.一项针对新诊断的1型（胰岛素依赖型）糖尿病患者的烟酰胺试验。
Diabetologia. 1990 Jul;33(7):444-6. doi: 10.1007/BF00404097.
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Double blind trial of nicotinamide in recent-onset IDDM (the IMDIAB III study).烟酰胺治疗近期发病的胰岛素依赖型糖尿病的双盲试验（IMDIAB III研究）
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Vitamin E and nicotinamide have similar effects in maintaining residual beta cell function in recent onset insulin-dependent diabetes (the IMDIAB IV study).维生素E和烟酰胺在维持近期发病的胰岛素依赖型糖尿病患者残余β细胞功能方面具有相似作用（IMDIAB IV研究）。
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