Origin of the anterior forebrain pathway.

The brain nuclei and pathways comprising the song system of oscine songbirds bear many similarities with circuits in other bird species and in mammals. This suggests that the song system evolved as a specialization of pre-existing circuits and may retain fundamental properties in common with those of other taxa. Here we review evidence for these similarities, including electrophysiological, morphological, and neurochemical data for identifying specific cell types. In addition, we discuss connectional data, addressing similarities in axonal projections among nuclei across taxa. We focus primarily on the anterior forebrain pathway, a circuit essential for song learning and vocal plasticity, because the evidence is strongest that this circuit is homologous to mammalian circuits. These fundamental similarities highlight the importance of comparative approaches; for example, understanding the role the anterior forebrain pathway plays in song plasticity may shed light on general principles of basal ganglia function. In addition, understanding specializations of such circuits in songbirds may illuminate specific innovations critical for vocal learning.