播散性掌跖汗孔角化症。1例皮损表皮DNA倍体异常的病例报告。
Porokeratosis palmaris et plantaris disseminata. Report of a case with abnormal DNA ploidy in lesional epidermis.
作者信息
Beers B, Jaszcz W, Sheetz K, Hogan D J, Lynch P J
机构信息
Department of Dermatology, University of Minnesota Hospital, Minneapolis.
出版信息
Arch Dermatol. 1992 Feb;128(2):236-9. doi: 10.1001/archderm.128.2.236.
BACKGROUND
Porokeratosis is believed to be a premalignant condition of the skin. Recent flow cytometric studies showing DNA aneuploidy in the epidermis of some types of porokeratosis support this conclusion. We describe a patient with porokeratosis palmaris et plantaris disseminata in whom abnormal DNA ploidy was found in lesional epidermis with the use of flow cytometry.
OBSERVATIONS
DNA flow cytometry of lesional epidermis from the back showed two populations of cells, one with diploid and the other with aneuploid DNA content and DNA index of 1.1 (hyperdiploid). The coefficient of variation of the diploid and aneuploid peaks was 2.1% and 4.1%, respectively.
CONCLUSIONS
Porokeratosis palmaris et plantaris disseminata, like other forms of porokeratosis, exhibits abnormal DNA ploidy in lesional epidermis. This finding underscores the premalignant nature of this and other forms of porokeratosis.
背景
掌跖播散性汗孔角化症被认为是一种皮肤癌前病变。最近的流式细胞术研究显示，某些类型的汗孔角化症的表皮存在DNA非整倍体，这一结论支持了这一观点。我们描述了一名掌跖播散性汗孔角化症患者，通过流式细胞术在其皮损表皮中发现了异常的DNA倍体。
观察结果
背部皮损表皮的DNA流式细胞术显示有两种细胞群，一种细胞的DNA含量为二倍体，另一种细胞的DNA含量为非整倍体，DNA指数为1.1（超二倍体）。二倍体和非整倍体峰的变异系数分别为2.1%和4.1%。
结论
掌跖播散性汗孔角化症与其他形式的汗孔角化症一样，在皮损表皮中表现出异常的DNA倍体。这一发现强调了这种及其他形式汗孔角化症的癌前性质。
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