Porokeratosis plantaris, palmaris, et disseminata. Report of a case and treatment with isotretinoin.

Porokeratosis plantaris, palmaris, et disseminata is a unique clinical entity characterized by the familial occurrence of multiple porokeratoses predominantly on the palms and soles but also on both sun-exposed and non-sun-exposed areas of the body. Since its original description in 1971 by Guss and colleagues, there has been only one other report of this syndrome. We have discovered a third family with this disorder and have used isotretinoin successfully to control the condition in one of the family's symptomatic members.