Caniça Manuela, Dias Ricardo, Nunes Baltazar, Carvalho Leonor, Ferreira Eugénia
Antibiotic Resistance Unit, Centre of Bacteriology1 and National Observatory for Health2, National Institute of Health Dr Ricardo Jorge, Lisboa, Portugal 3Paediatric Infectious Diseases Unit, Hospital de Dona Estefânia, Lisboa, Portugal.
J Med Microbiol. 2004 Sep;53(Pt 9):921-925. doi: 10.1099/jmm.0.45556-0.
The first investigation of Neisseria meningitidis isolated from a large area covering an appreciable population in Portugal, before the voluntary vaccination period with the serogroup C conjugate vaccine, is reported. The serogroups and antimicrobial susceptibility of 116 isolates were studied. Serogroups C (50.0 %), B (47.4 %) and W135 (2.6 %) were found. Serogroup C was most common in the 1-15-years-old group and B in the less than 1-year-old and over 16-years-old groups (P = 0.042). Clinical diagnosis of meningococcal disease was primarily meningitis for patients with serogroup C and meningitis associated with sepsis for those with serogroup B. Penicillin resistance was significantly associated with serogroup C (P < 0.001). This work reinforces the importance for public health of monitoring the serogroup and antimicrobial susceptibility of isolates from patients with invasive meningococcal disease.
本文报道了在葡萄牙引入C群结合疫苗自愿接种期之前，对从覆盖相当数量人口的大面积区域分离出的脑膜炎奈瑟菌进行的首次调查。研究了116株分离株的血清群和抗菌药物敏感性。发现血清群C（50.0%）、B（47.4%）和W135（2.6%）。血清群C在1至15岁年龄组中最为常见，血清群B在1岁以下和16岁以上年龄组中最为常见（P = 0.042）。C群患者的脑膜炎球菌病临床诊断主要为脑膜炎，B群患者的脑膜炎球菌病临床诊断主要为伴有败血症的脑膜炎。青霉素耐药性与血清群C显著相关（P < 0.001）。这项工作强化了监测侵袭性脑膜炎球菌病患者分离株的血清群和抗菌药物敏感性对公共卫生的重要性。
