Tsolia M N, Theodoridou M, Tzanakaki G, Vlachou V, Mostrou G, Stripeli F, Kalabalikis P, Pangalis A, Kafetzis D, Kremastinou J, Konstantopoulos A
Second Dept of Pediatrics P. and A. Kyriakou Children's Hospital, University of Athens School of Medicine, Thivon and Levadias St., 115 27, Athens, Greece.
Eur J Clin Microbiol Infect Dis. 2006 Jul;25(7):449-56. doi: 10.1007/s10096-006-0155-6.
Although invasive meningococcal disease caused by serogroup A is not prevalent in developed countries, a considerable number of cases were recently recorded in Greece. In this study, serogroup A meningococcal disease was compared prospectively with meningococcal disease caused by other serogroups, using similar settings of testing and management during a 5-year period between 1999 and 2003. The Neisseria meningitidis serogroup was determined in 262 cases. Serogroup B predominated, accounting for 158 (60%) of the cases. Serogroup A was second most frequent (19%), followed by serogroups W135 (11%), C (8%), and Y (2%). No cases due to serogroup C were recorded during the last year of the study. Patients with serogroup A disease were older and had a milder course compared to patients infected with serogroups B or C. Toxic appearance, purpura, thrombocytopenia, abnormal coagulation tests, and the need for admission to the intensive care unit, fluid resuscitation, inotropic drugs, and mechanical ventilation were less common. Although morbidity and mortality were lower in these patients, the differences were not significant. Serogroup B is predominant in our area, and the introduction of an effective vaccine against it is a priority. Serogroup A has emerged as the second most common serogroup, but the illness associated with it is milder.
虽然由A群脑膜炎球菌引起的侵袭性脑膜炎球菌病在发达国家并不常见，但最近希腊记录了相当数量的病例。在本研究中，在1999年至2003年的5年期间，采用相似的检测和管理方法，对A群脑膜炎球菌病与其他血清群引起的脑膜炎球菌病进行了前瞻性比较。对262例病例确定了脑膜炎奈瑟菌血清群。B群占主导，占病例的158例（60%）。A群是第二常见的（19%），其次是W135群（11%）、C群（8%）和Y群（2%）。在研究的最后一年未记录到C群引起的病例。与感染B群或C群的患者相比，A群疾病患者年龄较大，病程较轻。中毒表现、紫癜、血小板减少、凝血试验异常以及入住重症监护病房、液体复苏、使用血管活性药物和机械通气的需求较少见。虽然这些患者的发病率和死亡率较低，但差异不显著。B群在我们地区占主导，引入针对它的有效疫苗是当务之急。A群已成为第二常见的血清群，但与之相关的疾病较轻。
