Fouque D, Laville M, Boissel J P, Chifflet R, Labeeuw M, Zech P Y
Service de Néphrologie, Hôpital Edouard Herriot, Lyon.
BMJ. 1992 Jan 25;304(6821):216-20. doi: 10.1136/bmj.304.6821.216.
To determine whether low protein diets retard the development of end stage renal disease.
Meta-analysis of 46 trials since 1975, from which six randomised controlled trials were selected.
Five trials in Europe and one in Australia between 1982 and 1991.
890 patients with mild to severe chronic renal failure who were followed up for at least one year. 450 patients received a low protein diet and 440 a control diet.
Difference in protein intake between control and treated groups of at least 0.2 g protein/kg/day.
Number of renal deaths (the necessity to start dialysis or death of patient during study).
156 renal deaths were recorded, 61 in the low protein diet group and 95 in the control group, leading to an odds ratio of low protein to control of 0.54 with a 95% confidence interval of 0.37 to 0.79.
This result, obtained on a large population of patients suffering from chronic renal insufficiency, strongly supports the effectiveness of low protein diets in delaying the onset of end stage renal disease.
确定低蛋白饮食是否会延缓终末期肾病的发展。
对1975年以来的46项试验进行荟萃分析，从中选取了6项随机对照试验。
1982年至1991年间在欧洲进行了5项试验，在澳大利亚进行了1项试验。
890例轻至重度慢性肾衰竭患者，随访至少一年。450例患者接受低蛋白饮食，440例接受对照饮食。
对照组和治疗组之间的蛋白质摄入量差异至少为0.2克蛋白质/千克/天。
肾脏死亡人数（研究期间开始透析的必要性或患者死亡）。
记录到156例肾脏死亡，低蛋白饮食组61例，对照组95例，低蛋白组与对照组的比值比为0.54，95%置信区间为0.37至0.79。
在大量慢性肾功能不全患者中获得的这一结果，有力地支持了低蛋白饮食在延缓终末期肾病发病方面的有效性。
