Nowak-Göttl U, Besier E, Kreuz W D, Linde R, Koert M, Breddin H K, Kornhuber B
Zentrum der Kinderheilkunde, Stadtkrankenhaus Hanau, Main.
Klin Padiatr. 1992 Jan-Feb;204(1):37-42. doi: 10.1055/s-2007-1025320.
In order to establish an univariate nonparametric pediatric tolerance region platelet function has been investigated in 105 healthy children and adolescents. In comparison to adult normal values, the bleeding time is shortened, spontaneous platelet aggregation is enhanced as well as collagen-induced platelet aggregation. 30% of the children showed an increased disaggregation in ADP-induced aggregation. A slight delay was found in the spreading of thrombocytes. Platelet volume shifted to the left. Values of beta-thromboglobulin were raised. Compared to adult values no alterations could be found in platelet shape-change. Changes of platelet functions were more apparent in the younger children.
为了建立单变量非参数儿科耐受区间，对105名健康儿童和青少年的血小板功能进行了研究。与成人正常值相比，出血时间缩短，自发性血小板聚集增强，胶原诱导的血小板聚集也增强。30%的儿童在ADP诱导的聚集中出现解聚增加。发现血小板铺展略有延迟。血小板体积向左偏移。β-血小板球蛋白值升高。与成人值相比，未发现血小板形状改变有变化。血小板功能的变化在年幼儿童中更为明显。
