Briel R C, Kunz S, Zehles J
Z Geburtshilfe Perinatol. 1983 Sep-Oct;187(5):239-45.
ADP and collagen induced platelet aggregation were determined in 34 newborns immediately after birth. Blood was drawn from the pulsating not clamped umbilical vein. Parameters of aggregation were correlated to pH values of umbilical artery and vein, Apgar score and to the duration of the first and second stage of labor. No significant correlations were found between parameters of labor and platelet aggregation. It is demonstrated, however, that a decrease of the pH values in the umbilical artery and vein is well correlated with an increase of the main parameters of platelet aggregation. Changes of disaggregation of platelets were only moderate, they showed a tendency to decrease with falling pH values. Altogether there is an increase of platelet aggregability if pH values go down. The results emphasize that the changes of platelet function described should be regarded in the concept of therapy of newborns with severe acidosis or shock as they may accentuate preexisting hypercoagulability.
在34名新生儿出生后立即测定了ADP和胶原诱导的血小板聚集情况。血液取自搏动的未夹闭脐静脉。聚集参数与脐动脉和静脉的pH值、阿氏评分以及第一和第二产程的持续时间相关。未发现产程参数与血小板聚集之间存在显著相关性。然而，已证明脐动脉和静脉pH值的降低与血小板聚集主要参数的增加密切相关。血小板解聚的变化仅为中等程度，它们呈现出随pH值下降而降低的趋势。总体而言，pH值下降时血小板聚集性增加。结果强调，在治疗患有严重酸中毒或休克的新生儿时，应考虑到上述所描述的血小板功能变化，因为它们可能会加重已存在的高凝状态。
