一种用于海兔烯素的分子内狄尔斯-阿尔德方法：ophirin B的对映选择性全合成。
An intramolecular Diels-Alder approach to the eunicelins: enantioselective total synthesis of ophirin B.
作者信息
Crimmins Michael T, Brown Brandon H
机构信息
Department of Chemistry, Venable and Kenan Laboratories of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA.
出版信息
J Am Chem Soc. 2004 Aug 25;126(33):10264-6. doi: 10.1021/ja046574b.
PMID:15315437
Abstract
The enantioselective synthesis of the eunicellin ophirin B has been completed. A ring-closing metathesis provides efficient access to the oxonene ring, and a highly diastereoselective intramolecular Diels-Alder reaction results in the formation of the hydrobenzofuran portion of the molecule.
摘要
海扇软珊瑚素ophirin B的对映选择性合成已经完成。关环复分解反应为氧杂环丁二烯环的构建提供了有效途径，而高度非对映选择性的分子内狄尔斯-阿尔德反应则促成了该分子中氢化苯并呋喃部分的形成。
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