Maleki Shohreh, Keeney Scott
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 97, New York, NY 10021, USA.
Cell. 2004 Aug 20;118(4):404-6. doi: 10.1016/j.cell.2004.08.008.
It is well documented that the formation of the DNA double-strand breaks (DSBs) that initiate meiotic recombination is influenced by chromatin and larger scale chromosome organization, but the molecular nature of this influence has remained elusive. Several recent studies, including (this issue of Cell), shed light on this issue by revealing roles for posttranslational histone modifications in promoting DSB formation.
有充分的文献记载，引发减数分裂重组的DNA双链断裂（DSB）的形成受染色质和更大规模的染色体组织影响，但其影响的分子本质仍不清楚。最近的几项研究，包括（本期《细胞》杂志），通过揭示翻译后组蛋白修饰在促进DSB形成中的作用，为这个问题提供了线索。
