通过形成DNA双链断裂启动减数分裂重组：机制与调控

Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation.

作者信息

Keeney S, Neale M J

机构信息

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., Box 97, New York, NY 10021, USA.

出版信息

Biochem Soc Trans. 2006 Aug;34(Pt 4):523-5. doi: 10.1042/BST0340523.

DOI:10.1042/BST0340523

PMID:16856850

Abstract

Homologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining to protein-protein interactions important for DSB formation, the mechanism of an early step in the processing of Spo11-generated DSBs, and regulation of DSB formation by protein kinases.

摘要

同源重组对于大多数有性生物减数分裂期间准确的染色体分离至关重要。减数分裂重组由Spo11蛋白产生的双链DNA断裂（DSB）引发。我们在此综述了与DSB形成重要的蛋白质-蛋白质相互作用、Spo11产生的DSB加工早期步骤的机制以及蛋白激酶对DSB形成的调控有关的最新发现。