Valk-Lingbeek Merel E, Bruggeman Sophia W M, van Lohuizen Maarten
The Netherlands Cancer Institute, Department of Molecular Genetics, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Cell. 2004 Aug 20;118(4):409-18. doi: 10.1016/j.cell.2004.08.005.
Proteins from the Polycomb group (PcG) are epigenetic chromatin modifiers involved in cancer development and also in the maintenance of embryonic and adult stem cells. The therapeutic potential of stem cells and the growing conviction that tumors contain stem cells highlights the importance of understanding the extrinsic and intrinsic circuitry controlling stem cell fate and their connections to cancer.
多梳家族（PcG）蛋白是表观遗传染色质修饰因子，参与癌症发展以及胚胎和成年干细胞的维持。干细胞的治疗潜力以及越来越多人相信肿瘤中含有干细胞，这凸显了理解控制干细胞命运的外在和内在信号通路及其与癌症联系的重要性。
