Cryer Jonathan, Schipor Ioana, Perloff Joel R, Palmer James N
Division of Rhinology, Department of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pa., USA.
ORL J Otorhinolaryngol Relat Spec. 2004;66(3):155-8. doi: 10.1159/000079994.
The purpose of this study was to evaluate whether bacterial biofilms exist on the sinus mucosa surfaces of human subjects with recalcitrant chronic sinusitis. Scanning electron microscopy was used to evaluate patients with continued symptoms of chronic sinusitis despite prior appropriate medical and surgical management. Morphologic structures that confirm the presence of bacterial biofilms were identified on the sinus mucosa of patients infected with Pseudomonas aeruginosa, a known biofilm former. The presence of bacterial biofilms may explain the recalcitrant nature of some forms of chronic sinusitis.
本研究的目的是评估顽固性慢性鼻窦炎患者的鼻窦黏膜表面是否存在细菌生物膜。对于尽管先前进行了适当的药物和手术治疗但仍有慢性鼻窦炎持续症状的患者，使用扫描电子显微镜进行评估。在感染铜绿假单胞菌（一种已知的生物膜形成菌）的患者鼻窦黏膜上发现了可证实细菌生物膜存在的形态结构。细菌生物膜的存在可能解释了某些形式慢性鼻窦炎的顽固性。
