模拟生物膜的形成与发展：生物膜模型的最新进展

Guzmán-Soto Irene, McTiernan Christopher, Gonzalez-Gomez Mayte, Ross Alex, Gupta Keshav, Suuronen Erik J, Mah Thien-Fah, Griffith May, Alarcon Emilio I

Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, ON, K1Y4W7, Canada.

Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, K1H8M5, Canada.

iScience. 2021 Apr 17;24(5):102443. doi: 10.1016/j.isci.2021.102443. eCollection 2021 May 21.

Biofilm formation in living organisms is associated to tissue and implant infections, and it has also been linked to the contribution of antibiotic resistance. Thus, understanding biofilm development and being able to mimic such processes is vital for the successful development of antibiofilm treatments and therapies. Several decades of research have contributed to building the foundation for developing and biofilm models. However, no such thing as an "all fit" or biofilm models is currently available. In this review, in addition to presenting an updated overview of biofilm formation, we critically revise recent approaches for the improvement of and biofilm models.

生物膜在生物体内的形成与组织和植入物感染有关，并且还与抗生素耐药性的产生有关。因此，了解生物膜的形成过程并能够模拟这些过程对于抗生物膜治疗方法的成功开发至关重要。几十年的研究为生物膜模型的开发奠定了基础。然而，目前还没有一种“通用”的生物膜模型。在这篇综述中，除了对生物膜形成进行最新概述外，我们还批判性地回顾了改进生物膜模型的最新方法。