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[肺动脉血栓内膜剥脱术]

[Pulmonary thromboendarterectomy].

作者信息

Lausberg H F, Tscholl D, Schäfers H-J

机构信息

Abteilung für Thorax- und Herz-/Gefässchirurgie, Chirurgische Universitätsklinik, Homburg/Saar.

出版信息

Anaesthesist. 2004 Aug;53(8):748-52. doi: 10.1007/s00101-004-0725-x.

Abstract

Chronic thromboembolic pulmonary hypertension with concomitant right heart failure may develop as a sequela of acute pulmonary embolism with organization instead of thrombolysis of intravascular clots. Medical therapy aims at prevention of recurrent embolism by anticoagulation and vascular remodelling using vasodilator therapy. Lung transplantation or combined heart-lung transplantation is associated with unsatisfactory long-term results and comorbidity and therefore remains justified only in selected patients. Pulmonary thromboendarterectomy allows specific treatment of intravascular obstruction. This closed endarterectomy of the pulmonary arteries requires deep hypothermic circulatory arrest and can be performed with a perioperative mortality of less than 10%. The procedure significantly decreases pulmonary vascular resistance and often normalizes pulmonary hemodynamics and gas exchange. Postoperatively the patients' clinical condition improves and the majority have normal exercise capacity and activity.

摘要

伴有右心衰竭的慢性血栓栓塞性肺动脉高压可能作为急性肺栓塞的后遗症而发生,其特征是血管内血栓形成机化而非溶解。药物治疗旨在通过抗凝预防复发性栓塞,并使用血管扩张剂治疗进行血管重塑。肺移植或心肺联合移植的长期效果不尽人意且存在合并症,因此仅在特定患者中才合理。肺动脉血栓内膜剥脱术可对血管内阻塞进行特异性治疗。这种肺动脉的封闭式内膜剥脱术需要深度低温循环停止,围手术期死亡率可低于10%。该手术可显著降低肺血管阻力,常使肺血流动力学和气体交换恢复正常。术后患者的临床状况改善,大多数患者具有正常的运动能力和活动水平。

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