Langer F, Wilhelm W, Lausberg H, Schäfers H-J
Abteilung für Thorax- und Herz-Gefässchirurgie, Universitätskliniken des Saarlandes, Homburg/Saar.
Anaesthesist. 2004 Aug;53(8):753-8. doi: 10.1007/s00101-004-0715-z.
Pulmonary hypertension is a major risk factor in cardiac surgery and has significant impact on morbidity and mortality in the perioperative period. Nitric oxide (NO) is considered to be the gold standard for treatment of pulmonary hypertension in the perioperative setting. The aerosolized administration of the prostacyclin analogue iloprost is a new alternative with similar pulmonary-selective vasodilation and virtually no systemic side-effects. Relevant complications including increased postoperative bleeding have not been observed.
肺动脉高压是心脏手术中的一个主要危险因素，对围手术期的发病率和死亡率有重大影响。一氧化氮（NO）被认为是围手术期治疗肺动脉高压的金标准。前列环素类似物伊洛前列素的雾化吸入是一种新的替代方法，具有类似的肺选择性血管舒张作用，且几乎没有全身性副作用。尚未观察到包括术后出血增加在内的相关并发症。
