女性乳腺癌发病率与抗高血压药物的使用情况
Breast cancer incidence and use of antihypertensive medication in women.
作者信息
González-Pérez Antonio, Ronquist Gunnar, García Rodríguez Luis Alberto
机构信息
Centro Español de Investigación Farmacoepidemiológica, Madrid, Spain.
出版信息
Pharmacoepidemiol Drug Saf. 2004 Aug;13(8):581-5. doi: 10.1002/pds.910.
PURPOSE
Breast cancer is the most common cancer in women worldwide. We attempted to investigate the association between the risk of breast cancer and use of captopril and other antihypertensive medication.
METHODS
We performed a cohort study with a nested case-control analysis using the General Practitioner Research Database (GPRD) from the UK. We obtained adjusted estimates by fitting logistic regression models.
RESULTS
The incidence rate of breast cancer in our cohort of women aged 30-79 years was 156 per 100,000 person-years. Overall, incidence of breast cancer among users of antihypertensive drugs was no different from the one among non-users (odds ratio (OR): 1.0; 95% confidence interval (CI): 0.9-1.1). Captopril was not associated with a reduced risk of breast cancer (OR: 0.9; 95%CI: 0.6-1.3).
CONCLUSIONS
We did not find any clear association between antihypertensive drugs and risk of breast cancer. Similarly, captopril was not associated with a reduced risk of breast cancer risk.
目的
乳腺癌是全球女性中最常见的癌症。我们试图研究乳腺癌风险与卡托普利及其他抗高血压药物使用之间的关联。
方法
我们使用来自英国的全科医生研究数据库（GPRD）进行了一项队列研究，并进行巢式病例对照分析。我们通过拟合逻辑回归模型获得校正估计值。
结果
在我们30 - 79岁女性队列中，乳腺癌发病率为每10万人年156例。总体而言，抗高血压药物使用者中乳腺癌的发病率与非使用者无差异（比值比（OR）：1.0；95%置信区间（CI）：0.9 - 1.1）。卡托普利与降低乳腺癌风险无关（OR：0.9；95%CI：0.6 - 1.3）。
结论
我们未发现抗高血压药物与乳腺癌风险之间存在任何明确关联。同样，卡托普利与降低乳腺癌风险无关。
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