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Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery.

作者信息

Fura Aberra, Shu Yue-Zhong, Zhu Mingshe, Hanson Ronald L, Roongta Vikram, Humphreys W Griffith

机构信息

Bristol Myers Squibb, Pharmaceutical Research Institute, P.O. Box 5400, Princeton, New Jersey 08534, USA.

出版信息

J Med Chem. 2004 Aug 26;47(18):4339-51. doi: 10.1021/jm040066v.

DOI:10.1021/jm040066v
PMID:15317447
Abstract
摘要

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Role of pharmacologically active metabolites in drug discovery and development.药理活性代谢物在药物发现与开发中的作用。
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[Clinical pharmacologic aspects of cytochrome P-450 dependent biotransformation of drugs].
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