Nassar Alaa-Eldin F, Talaat Rasmy E
Department of Drug Metabolism, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA.
Drug Discov Today. 2004 Apr 1;9(7):317-27. doi: 10.1016/S1359-6446(03)03018-6.
Structural information on metabolites can be a considerable asset for enhancing and streamlining the process of developing new drug candidates. Modern approaches that generate and use metabolite structural information can accelerate the drug discovery and development process by eliminating potentially harmful candidates earlier in the process and improving the safety of new drugs. This review examines the relative merits of current and potential strategies for dealing with metabolite characterization.
代谢物的结构信息对于加强和简化新候选药物的研发过程可能是一项相当重要的资产。生成和使用代谢物结构信息的现代方法可以通过在过程早期淘汰潜在有害的候选物并提高新药的安全性来加速药物发现和开发过程。本综述探讨了处理代谢物表征的当前和潜在策略的相对优点。
